Nonsense and Missense Mutations in FCY2 and FCY1 Genes Are Responsible for Flucytosine Resistance and Flucytosine-Fluconazole Cross-Resistance in Clinical Isolates of Candida lusitaniae

The aim of this work was to elucidate the molecular mechanisms of flucytosine (5FC) resistance and 5FC/fluconazole (FLC) cross-resistance in 11 genetically and epidemiologically unrelated clinical isolates of Candida lusitaniae. We first showed that the levels of transcription of the FCY2 gene encod...

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Detalhes bibliográficos
Main Authors: Florent, Martine, Noël, Thierry, Ruprich-Robert, Gwenaël, Da Silva, Bruno, Fitton-Ouhabi, Valérie, Chastin, Christiane, Papon, Nicolas, Chapeland-Leclerc, Florence
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704628/
https://ncbi.nlm.nih.gov/pubmed/19414575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00880-08
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