Highly Sulfated K5 Escherichia coli Polysaccharide Derivatives Inhibit Respiratory Syncytial Virus Infectivity in Cell Lines and Human Tracheal-Bronchial Histocultures

Respiratory syncytial virus (RSV) exploits cell surface heparan sulfate proteoglycans (HSPGs) as attachment receptors. The interaction between RSV and HSPGs thus presents an attractive target for the development of novel inhibitors of RSV infection. In this study, selective chemical modification of...

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Detalhes bibliográficos
Main Authors: Cagno, Valeria, Donalisio, Manuela, Civra, Andrea, Volante, Marco, Veccelli, Elena, Oreste, Pasqua, Rusnati, Marco, Lembo, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135974/
https://ncbi.nlm.nih.gov/pubmed/24914125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02594-14
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