Hexon Hypervariable Region-Modified Adenovirus Type 5 (Ad5) Vectors Display Reduced Hepatotoxicity but Induce T Lymphocyte Phenotypes Similar to Ad5 Vectors

Hexon modification of adenovirus type 5 (Ad5) vectors with the hypervariable regions (HVRs) of Ad48 has been shown to allow Ad5HVR48 vectors to circumvent the majority of the preexisting Ad5-neutralizing antibodies. However, it remains unclear whether modifying hexon HVRs impacts innate or adaptive...

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Main Authors: Teigler, Jeffrey E., Penaloza-MacMaster, Pablo, Obeng, Rebecca, Provine, Nicholas M., Larocca, Rafael A., Borducchi, Erica N., Barouch, Dan H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Vaccines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135912/
https://ncbi.nlm.nih.gov/pubmed/24943382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00207-14
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