HuR Regulates Alternative Splicing of the TRA2β Gene in Human Colon Cancer Cells under Oxidative Stress

Hu antigen R (HuR) regulates stress responses through stabilizing and/or facilitating the translation of target mRNAs. The human TRA2β gene encodes splicing factor transformer 2β (Tra2β) and generates 5 mRNA isoforms (TRA2β1 to -5) through alternative splicing. Exposure of HCT116 colon cancer cells...

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Hauptverfasser: Akaike, Yoko, Masuda, Kiyoshi, Kuwano, Yuki, Nishida, Kensei, Kajita, Keisuke, Kurokawa, Ken, Satake, Yuzuru, Shoda, Katsutoshi, Imoto, Issei, Rokutan, Kazuhito
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135568/
https://ncbi.nlm.nih.gov/pubmed/24865968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00333-14
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