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Solid-Phase Chemoenzymatic Synthesis of C-Sialosides

The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI(2)-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as...

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Detalhes bibliográficos
Main Authors: Baytas, Sultan N., Wang, Qun, Karst, Nathalie A., Dordick, Jonathan S., Linhardt, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135478/
https://ncbi.nlm.nih.gov/pubmed/15387620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo0491298
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