Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis

DNA-damage response and repair are crucial to maintain genetic stability, and are consequently considered central to aging and longevity. Here, we investigate whether this pathway overall associates to longevity, and whether specific sub-processes are more strongly associated with longevity than oth...

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Bibliografiska uppgifter
Huvudupphovsmän: Debrabant, Birgit, Soerensen, Mette, Flachsbart, Friederike, Dato, Serena, Mengel-From, Jonas, Stevnsner, Tinna, Bohr, Vilhelm A, Kruse, Torben A, Schreiber, Stefan, Nebel, Almut, Christensen, Kaare, Tan, Qihua, Christiansen, Lene
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135411/
https://ncbi.nlm.nih.gov/pubmed/24518833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2013.299
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