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Simulation of B Cell Affinity Maturation Explains Enhanced Antibody Cross-Reactivity Induced by the Polyvalent Malaria Vaccine AMA1

Polyvalent vaccines use a mixture of Ags representing distinct pathogen strains to induce an immune response that is cross-reactive and protective. However, such approaches often have mixed results, and it is unclear how polyvalency alters the fine specificity of the Ab response and what those conse...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chaudhury, Sidhartha, Reifman, Jaques, Wallqvist, Anders
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135178/
https://ncbi.nlm.nih.gov/pubmed/25080483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401054
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