Quantitative Predictions of Binding Free Energy Changes in Drug-Resistant Influenza Neuraminidase

Quantitatively predicting changes in drug sensitivity associated with residue mutations is a major challenge in structural biology. By expanding the limits of free energy calculations, we successfully identified mutations in influenza neuraminidase (NA) that confer drug resistance to two antiviral d...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ripoll, Daniel R., Khavrutskii, Ilja V., Chaudhury, Sidhartha, Liu, Jin, Kuschner, Robert A., Wallqvist, Anders, Reifman, Jaques
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431292/
https://ncbi.nlm.nih.gov/pubmed/22956900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002665
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