Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.

The signalling pathways used by the GM-CSF receptor are currently unknown. Here we show that in human myeloid derived cells GM-CSF can stimulate; (i) the accumulation of PtdIns(3,4,5)P3; (ii) increases in p53/p56lyn and p62c-yes directed protein tyrosine kinase activities in anti-lyn and anti-c-yes...

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Pubblicato in:	EMBO J
Autori principali:	Corey, S, Eguinoa, A, Puyana-Theall, K, Bolen, J B, Cantley, L, Mollinedo, F, Jackson, T R, Hawkins, P T, Stephens, L R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413516/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8392933/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05929.x
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