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Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

The protein tyrosine kinase c-Src is negatively regulated by phosphorylation of Tyr527 in its carboxy-terminal tail. A kinase that phosphorylates Tyr527, called Csk, has recently been identified. We expressed c-Src in yeast to test the role of the SH2 and SH3 domains of Src in the negative regulatio...

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Bibliografiske detaljer
Main Authors: Superti-Furga, G, Fumagalli, S, Koegl, M, Courtneidge, S A, Draetta, G
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC413509/
https://ncbi.nlm.nih.gov/pubmed/7687537
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