Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice

Toll-like receptors (TLRs) play an important role in innate immunity to virus infections. We investigated the role of TLR3 in the pathogenesis of H5N1 and pandemic H1N1 (pH1N1) influenza virus infections in mice. Wild-type mice and those defective in TLR3 were infected with influenza A/HK/486/97 (H5...

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Bibliographische Detailangaben
Hauptverfasser: Leung, Y. H. Connie, Nicholls, John M., Ho, Chuk Kwan, Sia, Sin Fun, Mok, Chris K. P., Valkenburg, Sophie A., Cheung, Peter, Hui, Kenrie P. Y., Chan, Renee W. Y., Guan, Y., Akira, S., Peiris, J. S. Malik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for General Microbiology 2014
Schlagworte:
Animal
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135086/
https://ncbi.nlm.nih.gov/pubmed/24878639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.066258-0
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