Inhibition of Ca(V)3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone

RATIONALE: T-type calcium channels (T-channels) play an important role in controlling excitability of nociceptors. We have previously shown that a synthetic series of 5β-reduced steroids induce voltage-dependent blockade of T-currents in rat dorsal root ganglia (DRG) cells in vitro and induce potent...

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Main Authors: Ayoola, Christine, Hwang, Sung Mi, Hong, Sung Jun, Rose, Kirstin E., Boyd, Christopher, Bozic, Neda, Park, Ji-Yong, Osuru, Hari Prasad, DiGruccio, Michael R., Covey, Douglas F., Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135044/
https://ncbi.nlm.nih.gov/pubmed/24800894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3588-0
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