A Phase I, Pharmacokinetic, and Pharmacodynamic Study of Vorinostat in Combination with 5-Fluorouracil, Leucovorin, and Oxaliplatin in Patients with Refractory Colorectal Cancer

PURPOSE: We conducted a phase I study to determine the maximum tolerated dose (MTD) of vorinostat in combination with fixed doses of 5-Fluorouracil (5-FU), leucovorin, and oxaliplatin (FOLFOX). EXPERIMENTAL DESIGN: Vorinostat was given PO BID for 1 week every 2 weeks. FOLFOX was given on days 4 and...

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Detalhes bibliográficos
Main Authors: Fakih, Marwan G., Pendyala, Lakshmi, Fetterly, Gerald, Toth, Karoli, Zwiebel, James A, Espinoza-Delgado, Igor, Litwin, Alan, Rustum, Youcef M., Ross, Mary Ellen, Holleran, Julianne L., Egorin, Merrill J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134938/
https://ncbi.nlm.nih.gov/pubmed/19383814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2999
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