Role of Matrix Metalloproteinase Activity in the Neurovascular Protective Effects of Angiotensin Antagonism

Background and Purpose. Oxidative stress and matrix metalloproteinase (MMP) activity have been identified as key mediators of early vascular damage after ischemic stroke. Somewhat surprisingly, the angiotensin II type 1 receptor (AT1) blocker, candesartan, has been shown to acutely increase MMP acti...

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Autores principales: Ishrat, Tauheed, Kozak, Anna, Alhusban, Ahmed, Pillai, Bindu, Johnson, Maribeth H., El-Remessy, Azza B., Ergul, Adviye, Fagan, Susan C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134816/
https://ncbi.nlm.nih.gov/pubmed/25147751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/560491
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