Role of Matrix Metalloproteinase Activity in the Neurovascular Protective Effects of Angiotensin Antagonism

Background and Purpose. Oxidative stress and matrix metalloproteinase (MMP) activity have been identified as key mediators of early vascular damage after ischemic stroke. Somewhat surprisingly, the angiotensin II type 1 receptor (AT1) blocker, candesartan, has been shown to acutely increase MMP acti...

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Detalhes bibliográficos
Main Authors: Ishrat, Tauheed, Kozak, Anna, Alhusban, Ahmed, Pillai, Bindu, Johnson, Maribeth H., El-Remessy, Azza B., Ergul, Adviye, Fagan, Susan C.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134816/
https://ncbi.nlm.nih.gov/pubmed/25147751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/560491
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