Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease

Immunoglobulin A (IgA) nephropathy (IgAN), the leading cause of primary glomerulonephritis, is characterized by IgA1-containing immunodeposits in the glomeruli. IgAN is a chronic disease, with up to 40% of patients progressing to end-stage renal disease, with no disease-specific treatment. Multiple...

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Main Authors: Reily, Colin, Ueda, Hiroyuki, Huang, Zhi-Qiang, Mestecky, Jiri, Julian, Bruce A., Willey, Christopher D., Novak, Jan
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2014
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Review Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134797/
https://ncbi.nlm.nih.gov/pubmed/25152896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/197548
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