Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial

BACKGROUND: Chemoimmunotherapy has led to improved numbers of patients achieving disease response, and longer overall survival in young patients with chronic lymphocytic leukaemia; however, its application in elderly patients has been restricted by substantial myelosuppression and infection. We aime...

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Main Authors: O’Brien, Susan, Furman, Richard R, Coutre, Steven E, Sharman, Jeff P, Burger, Jan A, Blum, Kristie A, Grant, Barbara, Richards, Donald A, Coleman, Morton, Wierda, William G, Jones, Jeffrey A, Zhao, Weiqiang, Heerema, Nyla A, Johnson, Amy J, Izumi, Raquel, Hamdy, Ahmed, Chang, Betty Y, Graef, Thorsten, Clow, Fong, Buggy, Joseph J, James, Danelle F, Byrd, John C
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134524/
https://ncbi.nlm.nih.gov/pubmed/24332241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(13)70513-8
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