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ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: Implications for Parkinson's disease
Mitochondrial transcription factor A (TFAM) regulates mitochondrial biogenesis, which is downregulated by extracellular signal-regulated protein kinases (ERK1/2) in cells treated chronically with the complex I inhibitor 1-methyl-4-phenylpyridinium (MPP+). We utilized mass spectrometry to identify ER...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134365/ https://ncbi.nlm.nih.gov/pubmed/24768991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2014.04.008 |
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