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ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: Implications for Parkinson's disease

Mitochondrial transcription factor A (TFAM) regulates mitochondrial biogenesis, which is downregulated by extracellular signal-regulated protein kinases (ERK1/2) in cells treated chronically with the complex I inhibitor 1-methyl-4-phenylpyridinium (MPP+). We utilized mass spectrometry to identify ER...

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Detalhes bibliográficos
Main Authors: Wang, Kent Z.Q., Zhu, Jianhui, Dagda, Ruben K., Uechi, Guy, Cherra, Salvatore J., Gusdon, Aaron M., Balasubramani, Manimalha, Chu, Charleen T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134365/
https://ncbi.nlm.nih.gov/pubmed/24768991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2014.04.008
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