Enhanced sialylation and in vivo efficacy of recombinant human α-galactosidase through in vitro glycosylation

Human α-galactosidase A (GLA) has been used in enzyme replacement therapy for patients with Fabry disease. We expressed recombinant GLA from Chinese hamster ovary cells with very high productivity. When compared to an approved GLA (agalsidase beta), its size and charge were found to be smaller and m...

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Detalhes bibliográficos
Main Authors: Sohn, Youngsoo, Lee, Jung Mi, Park, Heung-Rok, Jung, Sung-Chul, Park, Tai Hyun, Oh, Doo-Byoung
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133871/
https://ncbi.nlm.nih.gov/pubmed/23527859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2013.46.3.192
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