The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans is confined to intestinal cells.

P-glycoproteins can cause multidrug resistance in mammalian tumor cells by active extrusion of cytotoxic drugs. The natural function of these evolutionarily conserved, membrane-bound ATP binding transport proteins is unknown. In mammals, P-glycoproteins are abundantly present in organs associated wi...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Lincke, C R, Broeks, A, The, I, Plasterk, R H, Borst, P
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1993
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC413375/
https://ncbi.nlm.nih.gov/pubmed/8096815
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