Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation

AIMS: Altered Ca(2+) handling in atrial fibrillation (AF) has been associated with dysregulated protein phosphatase 1 (PP1) and subcellular heterogeneities in protein phosphorylation, but the underlying mechanisms remain unclear. This is due to a lack of investigation into the local, rather than glo...

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Autors principals: Chiang, David Y., Li, Na, Wang, Qiongling, Alsina, Katherina M., Quick, Ann P., Reynolds, Julia O., Wang, Guoliang, Skapura, Darlene, Voigt, Niels, Dobrev, Dobromir, Wehrens, Xander H.T.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133595/
https://ncbi.nlm.nih.gov/pubmed/24812280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvu123
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