The HIV-1 Envelope Transmembrane Domain Binds TLR2 through a Distinct Dimerization Motif and Inhibits TLR2-Mediated Responses

HIV-1 uses a number of means to manipulate the immune system, to avoid recognition and to highjack signaling pathways. HIV-1 infected cells show limited Toll-Like Receptor (TLR) responsiveness via as yet unknown mechanisms. Using biochemical and biophysical approaches, we demonstrate that the trans-...

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Main Authors: Reuven, Eliran Moshe, Ali, Mohammad, Rotem, Etai, Schwarzter, Roland, Gramatica, Andrea, Futerman, Anthony H., Shai, Yechiel
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133399/
https://ncbi.nlm.nih.gov/pubmed/25121610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004248
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