Nitric Oxide from IFNγ-Primed Macrophages Modulates the Antimicrobial Activity of β-Lactams against the Intracellular Pathogens Burkholderia pseudomallei and Nontyphoidal Salmonella

Our investigations show that nonlethal concentrations of nitric oxide (NO) abrogate the antibiotic activity of β-lactam antibiotics against Burkholderia pseudomallei, Escherichia coli and nontyphoidal Salmonella enterica serovar Typhimurium. NO protects B. pseudomallei already exposed to β-lactams,...

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Hauptverfasser: Jones-Carson, Jessica, Zweifel, Adrienne E., Tapscott, Timothy, Austin, Chad, Brown, Joseph M., Jones, Kenneth L., Voskuil, Martin I., Vázquez-Torres, Andrés
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133387/
https://ncbi.nlm.nih.gov/pubmed/25121731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003079
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