CXCL12 Induces Connective Tissue Growth Factor Expression in Human Lung Fibroblasts through the Rac1/ERK, JNK, and AP-1 Pathways

CXCL12 (stromal cell-derived factor-1, SDF-1) is a potent chemokine for homing of CXCR4(+) fibrocytes to injury sites of lung tissue, which contributes to pulmonary fibrosis. Overexpression of connective tissue growth factor (CTGF) plays a critical role in pulmonary fibrosis. In this study, we inves...

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Main Authors: Lin, Chien-Huang, Shih, Chung-Huang, Tseng, Chih-Chieh, Yu, Chung-Chi, Tsai, Yuan-Jhih, Bien, Mauo-Ying, Chen, Bing-Chang
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133236/
https://ncbi.nlm.nih.gov/pubmed/25121739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104746
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