Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice

Down syndrome (DS) is marked by intellectual disability (ID) and early-onset of Alzheimer’s disease (AD) neuropathology, including basal forebrain cholinergic neuron (BFCN) degeneration. The present study tested the hypothesis that maternal choline supplementation (MCS) lessens hippocampal dysfuncti...

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Hoofdauteurs: Ash, Jessica A., Velazquez, Ramon, Kelley, Christy M., Powers, Brian E., Ginsberg, Stephen D., Mufson, Elliott J., Strupp, Barbara J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133151/
https://ncbi.nlm.nih.gov/pubmed/24932939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.06.001
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