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Pontine Norepinephrine Defects in Mecp2-null Mice Involve Deficient Expression of Dopamine β-hydroxylase but not a Loss of Catecholaminergic Neurons
Rett syndrome is a neurodevelopmental disorder caused by Mecp2 gene mutations. In RTT patients and Mecp2-null (Mecp2(−/Y)) mice, norepinephrine (NE) content drops significantly, which may play a role in breathing arrhythmia, sleep disorders and sudden death in RTT. However, the underlying mechanisms...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132834/ https://ncbi.nlm.nih.gov/pubmed/20193660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.02.156 |
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