Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression

Microglia, the resident CNS macrophages, have been implicated in the pathogenesis of Rett Syndrome (RTT), an X-linked neurodevelopmental disorder. However, the mechanism by which microglia contribute to the disorder is unclear and recent data suggest that microglia do not play a causative role. Here...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Schafer, Dorothy P, Heller, Christopher T, Gunner, Georgia, Heller, Molly, Gordon, Christopher, Hammond, Timothy, Wolf, Yochai, Jung, Steffen, Stevens, Beth
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961457/
https://ncbi.nlm.nih.gov/pubmed/27458802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15224
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