Unique Properties of Human β-Defensin 6 (hBD6) and Glycosaminoglycan Complex: SANDWICH-LIKE DIMERIZATION AND COMPETITION WITH THE CHEMOKINE RECEPTOR 2 (CCR2) BINDING SITE

Defensins are components of the innate immune system that promote the directional migration and activation of dendritic cells, thereby modulating the adaptive immune response. Because matrix glycosaminoglycan (GAG) is known to be important for these functions, we characterized the structural feature...

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Detalhes bibliográficos
Main Authors: De Paula, Viviane S., Pomin, Vitor H., Valente, Ana Paula
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132797/
https://ncbi.nlm.nih.gov/pubmed/24970887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572529
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