Inhibition of Hyaluronan Synthesis Protects against Central Nervous System (CNS) Autoimmunity and Increases CXCL12 Expression in the Inflamed CNS

Hyaluronan (HA) may have proinflammatory roles in the context of CNS autoimmunity. It accumulates in demyelinated multiple sclerosis (MS) lesions, promotes antigen presentation, and enhances T-cell activation and proliferation. HA facilitates lymphocyte binding to vessels and CNS infiltration at the...

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Hlavní autoři: Mueller, Andre Michael, Yoon, Bo Hyung, Sadiq, Saud Ahmed
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132791/
https://ncbi.nlm.nih.gov/pubmed/24973214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559583
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