B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

We have generated mice that lack the ability to produce immunoglobulin (Ig) kappa light chains by targeted deletion of J kappa and C kappa gene segments and the intervening sequences in mouse embryonic stem cells. In wild type mice, approximately 95% of B cells express kappa light chains and only ap...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Chen, J, Trounstine, M, Kurahara, C, Young, F, Kuo, C C, Xu, Y, Loring, J F, Alt, F W, Huszar, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413279/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8458340/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05722.x
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