B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

We have generated mice that lack the ability to produce immunoglobulin (Ig) kappa light chains by targeted deletion of J kappa and C kappa gene segments and the intervening sequences in mouse embryonic stem cells. In wild type mice, approximately 95% of B cells express kappa light chains and only ap...

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Main Authors: Chen, J, Trounstine, M, Kurahara, C, Young, F, Kuo, C C, Xu, Y, Loring, J F, Alt, F W, Huszar, D
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC413279/
https://ncbi.nlm.nih.gov/pubmed/8458340
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