Role of Protein Phosphatase 1 in Dephosphorylation of Ebola Virus VP30 Protein and Its Targeting for the Inhibition of Viral Transcription

The filovirus Ebola (EBOV) causes the most severe hemorrhagic fever known. The EBOV RNA-dependent polymerase complex includes a filovirus-specific VP30, which is critical for the transcriptional but not replication activity of EBOV polymerase; to support transcription, VP30 must be in a dephosphoryl...

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書誌詳細
主要な著者: Ilinykh, Philipp A., Tigabu, Bersabeh, Ivanov, Andrey, Ammosova, Tatiana, Obukhov, Yuri, Garron, Tania, Kumari, Namita, Kovalskyy, Dmytro, Platonov, Maxim O., Naumchik, Vasiliy S., Freiberg, Alexander N., Nekhai, Sergei, Bukreyev, Alexander
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2014
主題:
Microbiology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132779/
https://ncbi.nlm.nih.gov/pubmed/24936058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575050
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