A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD

Eukaryotic mRNAs with premature translation-termination codons (PTCs) are recognized and eliminated by nonsense-mediated mRNA decay (NMD). NMD substrates can be degraded by different routes that all require phosphorylated UPF1 (P-UPF1) as a starting point. The endonuclease SMG6, which cleaves mRNA n...

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Bibliographic Details
Main Authors: Nicholson, Pamela, Josi, Christoph, Kurosawa, Hitomi, Yamashita, Akio, Mühlemann, Oliver
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132754/
https://ncbi.nlm.nih.gov/pubmed/25053839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku645
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