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A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD
Eukaryotic mRNAs with premature translation-termination codons (PTCs) are recognized and eliminated by nonsense-mediated mRNA decay (NMD). NMD substrates can be degraded by different routes that all require phosphorylated UPF1 (P-UPF1) as a starting point. The endonuclease SMG6, which cleaves mRNA n...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132754/ https://ncbi.nlm.nih.gov/pubmed/25053839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku645 |
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