Microscopic mechanism of DNA damage searching by hOGG1

The DNA backbone is often considered a track that allows long-range sliding of DNA repair enzymes in their search for rare damage sites in DNA. A proposed exemplar of DNA sliding is human 8-oxoguanine ((o)G) DNA glycosylase 1 (hOGG1), which repairs mutagenic (o)G lesions in DNA. Here we use our high...

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Hlavní autoři: Rowland, Meng M., Schonhoft, Joseph D., McKibbin, Paige L., David, Sheila S., Stivers, James T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132736/
https://ncbi.nlm.nih.gov/pubmed/25016526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku621
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