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G-quadruplexes within prion mRNA: the missing link in prion disease?
Cellular ribonucleic acid (RNA) plays a crucial role in the initial conversion of cellular prion protein PrP(C) to infectious PrP(Sc) or scrapie. The nature of this RNA remains elusive. Previously, RNA aptamers against PrP(C) have been isolated and found to form G-quadruplexes (G4s). PrP(C) binding...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132711/ https://ncbi.nlm.nih.gov/pubmed/25030900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku559 |
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