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Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways

The findings that microRNAs (miRNAs) are essential for early development in many species and that embryonic miRNAs can reprogram somatic cells into induced pluripotent stem cells suggest that these miRNAs act directly on transcriptional and chromatin regulators of pluripotency. To elucidate the tran...

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Bibliografske podrobnosti
Main Authors: Gruber, Andreas J., Grandy, William A., Balwierz, Piotr J., Dimitrova, Yoana A., Pachkov, Mikhail, Ciaudo, Constance, van Nimwegen, Erik, Zavolan, Mihaela
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
RNA
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132708/
https://ncbi.nlm.nih.gov/pubmed/25030899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku544
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