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Identification of Key Residues in Transmembrane 4 Responsible for the Secondary, Low-Affinity Conformation of the Human β(1)-Adrenoceptor
The β(1)-adrenoceptor exists in two agonist conformations/states: 1) a high-affinity state where responses to catecholamines and other agonists (e.g., cimaterol) are potently inhibited by β(1)-adrenoceptor antagonists, and 2) a low-affinity secondary conformation where agonist responses, particularl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132118/ https://ncbi.nlm.nih.gov/pubmed/24608857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.091587 |
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