CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

Lignende værker

• The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.
  af: Chu, D H, et al.
  Udgivet: (1996)
• Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity.
  af: D'Oro, U, et al.
  Udgivet: (1996)
• Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases.
  af: Hurley, T R, et al.
  Udgivet: (1993)
• Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice
  af: Baker, Matthew, et al.
  Udgivet: (2000)
• The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.
  af: Gervais, F G, et al.
  Udgivet: (1993)