CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

CD45 is a tyrosine phosphatase expressed in all hematopoietic cells which is important for signal transduction through the T cell antigen receptor (TCR). Studies using CD45-deficient cells have revealed that Lck, a tyrosine kinase thought to be essential for TCR signaling, is hyperphosphorylated on...

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Bibliografiska uppgifter

I publikationen:	EMBO J
Huvudupphov:	Sieh, M, Bolen, J B, Weiss, A
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Publishing Group 1993
Ämnen:	Research Article
Länkar:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413208/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8428589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05659.x
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