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Autoantibodies to calpastatin (an endogenous inhibitor for calcium-dependent neutral protease, calpain) in systemic rheumatic diseases.

We identified an autoantibody that reacts with calpastatin [an inhibitor protein of the calcium-dependent neutral protease calpain (EC 3.4.22.17)]. In early immunoblot studies, sera from patients with rheumatoid arthritis (RA) recognized unidentified 60-, 45-, and 75-kDa proteins in HeLa cell extrac...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Mimori, T, Suganuma, K, Tanami, Y, Nojima, T, Matsumura, M, Fujii, T, Yoshizawa, T, Suzuki, K, Akizuki, M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41320/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7638179/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.16.7267
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