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The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B.

We have examined the interaction of the NF-kappa B precursor p105 with NF-kappa B subunits. Similar to an I kappa B molecule, p105 associates in the cytoplasm with p50 or p65. Through this assembly, p105 efficiently blocks nuclear transfer of either subunit. Moreover, the p105 protein inhibits DNA b...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Naumann, M, Wulczyn, F G, Scheidereit, C
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 1993
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413194/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8428580/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05647.x
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