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Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B.

We have studied the role of protein turnover in the induction of NF-kappa B DNA binding activity. Treatment of cells with tumour necrosis factor (TNF), double-stranded RNA (dsRNA), or phorbol esters is shown to be associated with an increase in the rate of p105 to p50 processing, and the loss of imm...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mellits, K H, Hay, R T, Goodbourn, S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1993
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC310617/
https://ncbi.nlm.nih.gov/pubmed/8255759
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