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Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.

In fission yeast, the M-phase inducing kinase, a complex of p34cdc2 and cyclin B, is maintained in an inhibited state during interphase due to the phosphorylation of Cdc2 at Tyr15. This phosphorylation is believed to be carried out primarily by the Wee1 kinase. In human cells the negative regulation...

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Bibliografiske detaljer
Udgivet i:EMBO J
Principais autores: McGowan, C H, Russell, P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1993
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413177/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8428596/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05633.x
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