Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.

In fission yeast, the M-phase inducing kinase, a complex of p34cdc2 and cyclin B, is maintained in an inhibited state during interphase due to the phosphorylation of Cdc2 at Tyr15. This phosphorylation is believed to be carried out primarily by the Wee1 kinase. In human cells the negative regulation...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	McGowan, C H, Russell, P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8428596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05633.x
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