Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice

Common polymorphisms in the first intron of FTO are associated with a increased body weight in adults. Previous studies have suggested that a CUX1 regulatory element within the implicated FTO region controls expression of FTO and the nearby ciliary gene, RPGRIP1L. Given the role of ciliary genes in...

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Hauptverfasser: Stratigopoulos, George, Martin Carli, Jayne F., O’Day, Diana R., Wang, Liheng, LeDuc, Charles A., Lanzano, Patricia, Chung, Wendy K., Rosenbaum, Michael, Egli, Dieter, Doherty, Daniel A., Leibel, Rudolph L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131684/
https://ncbi.nlm.nih.gov/pubmed/24807221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.04.009
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