Nitric oxide enhances Th9 cell differentiation and airway inflammation

Th9 cells protect hosts against helminthic infection but also mediate allergic disease. Here we show that nitric oxide (NO) promotes Th9 cell polarization of murine and human CD4(+) T cells. NO de-represses the tumor suppressor gene p53 via nitrosylation of Mdm2. NO also increases p53-mediated IL-2...

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Hoofdauteurs: Niedbala, Wanda, Besnard, Anne-Gaelle, Nascimento, Daniele Carvalho, Donate, Paula Barbim, Sonego, Fabiane, Yip, Edwin, Guabiraba, Rodrigo, Chang, Hyun-Dong, Fukada, Sandra Y., Salmond, Robert J., Schmitt, Edgar, Bopp, Tobias, Ryffel, Bernhard, Liew, Foo Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131005/
https://ncbi.nlm.nih.gov/pubmed/25099390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5575
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