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Prostate tumor development and androgen receptor function alterations in a new mouse model with ERG overexpression and PTEN inactivation

Gene fusions involving ETS transcription factors (predominantly ERG and ETV1) and PTEN deletions are prevalent in the prostate cancer genome. This report describes a novel mouse model that overexpresses ERG and lacks PTEN with the majority of mice developing prostate tumors by 6 mo. Biological mecha...

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Detalhes bibliográficos
Main Authors: Srivastava, Anjali, Price, Douglas K, Figg, William D
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130720/
https://ncbi.nlm.nih.gov/pubmed/25007053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29694
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