Long-Term Reproducible Expression in Human Fetal Liver Hematopoietic Stem Cells with a UCOE-Based Lentiviral Vector

Hematopoietic Stem Cell (HSC) targeted gene transfer is an attractive treatment option for a number of hematopoietic disorders caused by single gene defects. However, extensive methylation of promoter sequences results in silencing of therapeutic gene expression. The choice of an appropriate promote...

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Bibliografiska uppgifter
Huvudupphovsmän: Dighe, Niraja, Khoury, Maroun, Mattar, Citra, Chong, Mark, Choolani, Mahesh, Chen, Jianzhu, Antoniou, Michael N., Chan, Jerry K. Y.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130605/
https://ncbi.nlm.nih.gov/pubmed/25118036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104805
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