Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in mice

The development of an effective T cell based HIV vaccine would need to elicit cell mediated immune responses with superior magnitude, breadth, and quality. Since blocking the interactions between inhibitory receptors with their associated ligands using soluble PD-1 (sPD-1) and soluble Tim-3 (sTim-3)...

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Главные авторы: Xiao, Lijun, Wang, Dimin, Sun, Caijun, Li, Pingchao, Jin, Yi, Feng, Liqiang, Chen, Ling
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2014
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130272/
https://ncbi.nlm.nih.gov/pubmed/24326266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.27340
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